How NMN Repairs DNA And Reverses Aging

How NMN Repairs DNA And Reverses Aging

NMN (Nicotinamide Mononucleotide) has become more and more prominent in the field of longevity research and supplementation for a variety of reasons including its ability to facilitate DNA repair. More importantly, the research has shown dramatic improvements in current health and wellness.

HOW DOES DNA DAMAGE HAPPEN

DNA damage is not an uncommon occurrence. DNA damage is accelerated by exogenous and endogenous sources. Exogenous sources of DNA damage include UV radiation from the sun, polluted air, and pesticides on the food we consume. Endogenous sources of DNA damage include free radical damage caused by oxidative stress.

The majority of humans are exposed to all of these sources of DNA damage and this has become an unavoidable problem we all will eventually face as we grow older and this damage accumulates. DNA damage is happening right now, but the human body has the ability to detect and repair damaged DNA. This happens all of the time in our bodies.


As damage occurs in one cell or section of DNA, a chain reaction of damage is likely to occur leading to inflammation in nearby cells and an increased risk of developing neurodegenerative and metabolic diseases which ultimately lead to a shorter lifespan. Worse, if the damage propagates, mutations can cause cancers.

NMN AND DNA REPAIR

Where does NMN come into play? NMN is a precursor molecule to NAD+ (nicotinamide adenine dinucleotide) which is one of the main characters in powering DNA repair. NAD+ levels do naturally decrease with age, but through NMN supplementation, you can bring your levels back up to keep DNA repair a functioning process of the body.
NAD+ is found in every cell in the body and activates sirtuins to regulate metabolism and cellular repair. It also interacts with PARP1 (poly [ADP-ribose] polymerase 1) another protein that repairs damaged DNA. Both sirtuins and PARP1 require NAD+ in order to properly function.


Another molecule called DBC1 plays a role in this process; however, it is detrimental to the process of DNA repair and longevity. DBC1 inhibits the actions of sirtuins, more specifically SIRT1. It also binds tightly to PARP1 resulting in the inability to perform DNA repair. NAD+ also binds with DBC1 leaving PARP1 free to get to work. The more NAD+ available in your body, the more DNA repair is able to take place.
Dr. Meredith Warner, Orthopedic Surgeon

ABOUT THE AUTHOR

Dr. Meredith Warner is the creator of Well Theory and The Healing Sole. She is a board-certified Orthopedic Surgeon and Air Force Veteran.


She is on a mission to disrupt traditional medicine practices and promote betterment physically, spiritually and mentally to many more people. She advocates for wellness and functional health over big pharma so more people can age vibrantly with more function and less pain.


At Well Theory, Our surgeon-designed products are FDA Registered and formulated to help people:


  • Manage the symptoms of musculoskeletal pain
  • Recover vibrantly from orthopedic related surgeries
  • Fill the gaps in our daily diets
  • Manage pain associated with inflammation
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